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Zollinger-Ellison syndrome (ZES) is characterized by refractory peptic ulcer disease, diarrhea, and gastric acid hypersecretion as a result of a functional pancreatic or duodenal neuroendocrine tumor (NET). ZES is also referred to as gastrinoma.
Tests generally appear in the order most useful for common clinical situations
| Test name: Gastrin |
| ARUP #: 0070075 |
| Methodology: Quantitative Chemiluminescent Immunoassay |
| Use: Use in diagnosis of ZES Patient should be fasting |
| Limitations: Proton pump inhibitor (PPI) treatment and atrophic gastritis may interfere with test |
| Test name: Gastric Analysis |
| ARUP #: 0020149 |
| Methodology: Quantitative Titration |
| Use: Use in diagnosis of ZES |
| Limitations: If on PPI, must stop for 2 weeks |
| Test name: Gastrin by Immunohistochemistry |
| ARUP #: 2003896 |
| Methodology: Immunohistochemistry |
| Use: Aid in histologic diagnosis of gastrinoma Stained and returned to client pathologist for interpretation; consultation available if needed |
| Test name: Chromogranin A by Immunohistochemistry |
| ARUP #: 2003830 |
| Methodology: Immunohistochemistry |
| Use: Aid in histologic identification of neuroendocrine tissue Stained and returned to client pathologist; consultation available if needed |
| Test name: Synaptophysin by Immunohistochemistry |
| ARUP #: 2004139 |
| Methodology: Immunohistochemistry |
| Use: Aid in histologic diagnosis of gastrinoma Stained and returned to client pathologist; consultation available if needed |
| Test name: Cytokeratin 7 (CK 7) by Immunohistochemistry |
| ARUP #: 2003854 |
| Methodology: Immunohistochemistry |
| Use: Aid in histologic diagnosis of gastrinoma Stained and returned to client pathologist; consultation available if needed |
| Test name: Ki-67 with Interpretation by Immunohistochemistry |
| ARUP #: 2007182 |
| Methodology: Immunohistochemistry |
| Use: Aid in grading of NET Determines mitotic rate of tissue Stained and resulted by ARUP |
| Test name: Neuron Specific Enolase, Polyclonal (NSE P) by Immunohistochemistry |
| ARUP #: 2004052 |
| Methodology: Immunohistochemistry |
| Use: Aid in histologic identification of neural and neuroendocrine tissue Stained and returned to client pathologist; consultation available if needed |
| Test name: Pan Cytokeratin (AE1,3) by Immunohistochemistry |
| ARUP #: 2003433 |
| Methodology: Immunohistochemistry |
| Use: Aid in histologic identification of epithelial tissue Stained and returned to client pathologist; consultation available if needed |
| Test name: Protein Gene Product (PGP) 9.5 by Immunohistochemistry |
| ARUP #: 2004091 |
| Methodology: Immunohistochemistry |
| Use: Aid in histologic diagnosis of gastrinoma Stained and returned to client pathologist; consultation available if needed |